Chemotherapy in Control of Malaria
Dra. Daily
Chemotherapy
Learning objectives
Wish list
Treatment
Other considerations
Mechanisms of action
Main treatment
Main prophylaxis
Life cycle
Quinolines
Quinolines
Quinolines
Quinine
Quinine
Quinine
Quinine
Development
Chloroquine
Chloroquine
Mechanism of action
Mechanism of action
Drug resistance
Chloroquine
Drug Resistance
Drug Resistance
Drug Resistance
Drug Resistance
Measuring
Drug resistance
Mefloquine
Mefloquine
Mefloquine
Antifolates
Folate biosynthesis
Figure
Figure
Figure
Drug resistance
Drug resistance
Increase in IC
SP still used
New class
Artemisinins
Artemisinins
Artemisinins
Artemisinins
ART
Artemisinins
Coartem
Text
Reports
Artemisinin
ART resistance
Figure
Prolonged therapy
Atovaquone
Atovaquone
Atovaquone
If severe malaria
Recap
Case 1
Treatment options
Case 2
Some P falciparum
The New England
Case 3
Treatment for P vivax
Primaquine
Primaquine
Terminal prophylaxis
Primaquine
Case 4
P vivax
How widespread
How widespread
Text
Study description
Figure
Results
Time to parasite
Case 5
Treatment for P ovale
Case 4
P knowelsi
Preventative measures
CDC resources
Resources
